You'll no longer have to click through to the Other Locations menu when saving files in Word, Excel, or PowerPoint. On the bright side, for those who prefer saving files locally, going this route makes life easier. You also won't be able to experience any of the built-in collaboration features in Office 365, meaning you can't share edits with your friends or coworkers. This means that you won't be able to see all of your changes to a file, from the web, or computer without worrying about manual saves.
So, what happens when you work around OneDrive and instead save locally in these Office 365 apps? Well, for one, you'll no longer have access to the version history feature of Office 365. When finished, press OK. You'll need to restart Word, Excel, or PowerPoint for these changes to take effect. You'll also want to make sure that the Save to Computer by default box is checked.